Drug discovery pipeline
Our pipeline includes novel drug targets with genetic linkage and indication expansion opportunities at all stages of development - all with highly specific patient stratification biomarkers.
Therapeutic area
Indication
Patient stratification biomarkers
Novel targets
Repositioning opportunities
Active molecules
In vitro hit validation
In vivo hit validation
Ageing
Osteoarthritis
Autoimmune
Rheumatoid Arthritis
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High-resolution patient stratification results:
- 520 Disease risk loci
- 250 Risk associated genes mapped to disease associated mechanisms
- >30 Druggable targets
- 57 Known active compounds
Autoimmune
Sjögren’s syndrome
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High-resolution patient stratification results:
- 717 Disease risk loci
- 299 Risk associated genes mapped to disease associated mechanisms
- >30 Druggable targets
- 263 Known active compounds
Cardiovascular
Atrial fibrillation
Cardiovascular
Cardiovascular disease
Infectious
COVID-19
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High-resolution patient stratification results:
- 158 Disease risk loci
- 88 Risk associated genes mapped to disease associated mechanisms
- 23 Druggable targets
- 59 Known active compounds
Metabolic
Diabetes type 2 complications
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High-resolution patient stratification results:
- 35 Disease risk loci
- 20 Risk associated genes mapped to disease associated mechanisms
- 8 Druggable targets
- 120 Known active compounds
Neurological
ALS
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High-resolution patient stratification results:
- 73 Disease risk loci
- 33 Risk associated genes mapped to disease associated mechanisms
- 16 Druggable targets
- 19 Known active compounds
Neurological
Alzheimer's disease
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High-resolution patient stratification results:
- 267 Disease risk loci
- 113 Risk associated genes mapped to disease associated mechanisms
- >30 Druggable targets
- 732 Known active compounds
Neurological
Migraine
Neurological
Parkinson's disease
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High-resolution patient stratification results:
- 707 Disease risk loci
- 341 Risk associated genes mapped to disease associated mechanisms
- >30 Druggable targets
- 2611 Known active compounds
Neuropsychiatric
Schizophrenia
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High-resolution patient stratification results:
- 125 Disease risk loci
- 85 Risk associated genes mapped to disease associated mechanisms
- >30 Druggable targets
- 155 Known active compounds
Respiratory
Asthma
(non-T2)
(non-T2)
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High-resolution patient stratification results:
- 570 Disease risk loci
- >200 Risk associated genes mapped to disease associated mechanisms
- >30 Druggable targets
- 281 Known active compounds
Respiratory
Asthma
(T2-high)
(T2-high)
Respiratory
COPD
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High-resolution patient stratification results:
- 359 Disease risk loci
- 163 Risk associated genes mapped to disease associated mechanisms
- >30 Druggable targets
- >300 Known active compounds
Women’s health
Endometriosis
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High-resolution patient stratification results:
- 233 Disease risk loci
- 136 Risk associated genes mapped to disease associated mechanisms
- >30 Druggable targets
- 74 Known active compounds
Last updated May 24, 2023
Alopecia
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