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Taking you from biobank to bedside

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Understand the biology

we identify the mechanistic  drivers of complex biology and determine causality

 

 

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Find the biomarkers

we discover biomarkers that stratify patients with the underlying disease mechanisms

 

 

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Translate to practice

we translate our biomarkers to clinical practice in the form of highly-scalable genotypic tests to enable rapid real-world stratification

Mechanism-based biomarkers-min

Mechanism-based biomarkers

At the heart of our approach are our mechanistic biomarkers.

Our biomarkers stratify clinically relevant patient subgroups by causal biology of their disease and/or treatment response.

From this stratification we can accurately map patients to drug targets, clinical trials, and treatments with unprecedented genetic evidence.

We've discovered mechanism-based biomarkers for all clinically relevant patient subgroup in over 60 diseases and their endotypes.

heart-rateImproving disease prediction, diagnosis and treatment

medsDe-risking drug discovery, development, and launch

Mapping patients to the right clinical trials and treatments

Our mechanistic biomarkers maximize clinical value at every stage of healthcare and drug development.

In healthcare
PrecisionLife biomarkers support accurate diagnosis, triage, and personalized treatment selection by identifying patients based on the molecular mechanisms driving their disease. This enables more precise, effective, and cost-efficient care.

In clinical development
We help design faster, smaller, and more successful trials by identifying 'super responder' subgroups and providing companion diagnostic biomarkers that accelerate regulatory approval and market access for new therapies.

In drug discovery
Our patient stratification biomarkers help de-risk target selection by validating mechanistic relevance in specific patient subgroups. This informs a target’s product profile, prevalence, druggability, expected clinical efficacy, and commercial potential.

Mapping patients to the right clinical trials and treatment-min (1)
Reduce to clinical practice-min

Clinically actionable insights

Our biomarkers are reduced to clinical practice as highly-scalable, low-cost and non-invasive mechanostic tests based on the Axiom genotyping array.

Mechanostics® rapidly determine an individual's disease risk and mechanistic cause of disease:

Optimizing clinical trial design and patient recruitment
Screening populations to identify at risk patients
Enabling fast and accurate differential triage of patients in clinic
Guiding diagnostic decisions and treatment selection
Supporting market adoption as complementary diagnostic tools

Discovering subgroups in diseases with no known genetic associations

Mechanism-based patient stratification biomarkers accurately predict patient subgroups and their responses to treatment even in diseases with no previous genetic associations.

An example is our study in ME/CFS (myalgic encephalomyelitis / chronic fatigue syndrome), a highly heterogenous disease that is debilitating for millions of patients, costing billions of dollars. 

30 years of international ME/CFS research had yielded no effective diagnostic tests, disease modifying treatments, or reproducible genetic associations.

That was until we analyzed genotype data from 2382 patients to find 14 novel genetic associations – enhancing disease understanding and enabling mechanistic stratification of it's biology for the very first time.

In the figure below, the green patient subgroup (27% of cases) was found to have a specific fatigue presentation due to defects in mitochondrial respiration.

Only ME/CFS patients in this group will respond to a drug targeting that gene. Patients with other disease mechanisms will respond to different drugs.

For example, the blue subgroup (22% of cases) whose ME/CFS is mediated by genes involved in neurotransmitter precursor transport and show symptoms that include cognitive impairment.

These findings highlight how mechanistic stratification and the biomarkers to identify the right patients is essential for improving drug development and healthcare.

MECFS Stratification-min
PAPER

Genetic Risk Factors for ME/CFS Identified with Combinatorial Analysis

Journal of Translational Medicine

 

Precision medicine for complex, chronic diseases

Precision medicine tests

Our proprietary mechanism-based biomarkers are applied to simple genotypic tests to predict disease risk and select patients most likely to respond to treatments.

Combinatorial Analytics

Combinatorial analytics is uniquely capable of revealing the complex biology and causality of chronic diseases at an unprecedented level of detail.