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Knowledge Hub

We're leading global efforts to predict and prevent complex diseases. Explore our publications, disease studies, webinars, thought leadership, and more.

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Publication

Increasing Healthspan - Predicting & Preventing Complex Chronic Diseases

By building a deeper understanding of disease biology we're creating a new generation of more accurate diagnostics tools and personalized and preventative medicines

Publication

New ALS disease drivers identified in genetically defined patient subgroups

First genetic evidence for targets modulated by existing therapies indicated for MND and its symptoms, such as riluzole, retigabine and baclofen.

Blog

Podcast - Overcoming obstacles in personalized medicine

Hear how we're overcoming the major challenges in precision medicine to predict and prevent complex disease.

Publication

ALS actively protective biology, novel causal targets and mechanistic biomarkers

Transformational causative combinatorial analysis of ALS/MND presented at the NEALS Annual Meeting 2024

Publication

Stratifying of Alzheimer’s disease leads to the identification of actively protective biologies

Our mechanism-based stratification of Alzheimer’s disease patients has led to the identification of novel targets, repurposing opportunities and actively protective biology

Publication

Patient Stratification of Two Asthma Populations Reveals Distinct Genetic and Mechanistic Differences

PrecisionLife prioritized 10 of the most tractable gene targets specific to T2-low asthma in both UK Biobank and GASP asthma populations

Blog

Driving Precision Medicine in CNS Disorders

Disorders of the central nervous system are a major focus for PrecisionLife.  We’ve completed analyses in more than a dozen indications and continue to add to the list as datasets become available.

Publication

Genetic Risk Factors for Severe and Fatigue Dominant Long COVID

PrecisionLife identified the first detailed genetic risk factors for long COVID and common mechanisms with ME/CFS and other complex diseases

Blog

Beginning to Unravel the Biological Drivers of ME

We have for the first time potentially identified some of the different genetic mechanisms causing ME/CFS and used this to stratify patients

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