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PrecisionLife and Metrodora Institute Launch ME/CFS and Long Covid Clinical Trials

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PrecisionLife and Metrodora Institute Launch Clinical Trials to Accelerate the Diagnosis and Treatment of ME/CFS and Long Covid Patients

  • Up to 1,000 patients being recruited into targeted precision medicine clinical trials expected to readout results as early as this year
  • Trials are designed to provide validation of safety and effectiveness for novel diagnostics and innovative clinical care pathways in ME/CFS and Long Covid

SALT LAKE CITY, US and OXFORD, UK – 13 May 2024 – The leading US multi-specialty healthcare center, Metrodora Institute, and pioneering precision medicine company, PrecisionLife, announce the start of recruitment on a cohort of up to 1,000 patients into clinical trials to evaluate new diagnosis and treatment options for ME/CFS, Long Covid, and related disorders.

The partners have developed genotypic diagnostic tests that are now being evaluated for their ability to provide clinicians with an accurate view of a patient’s risk of a specific disease. Ultimately, using the molecular profile of their underlying disease mechanisms, these tests will also be used to recruit cohorts to evaluate the effectiveness of drug repurposing candidates targeting specific disease mechanisms to improve patient outcomes. 

The partnership builds on PrecisionLife’s unique insights into the mechanisms driving ME/CFS and Long Covid, Metrodora’s deep clinical and research expertise, and collaborations with leading patient charities including Action for ME and the world’s largest ME/CFS study, DecodeME. Recruitment for the trial will open to US residents in June and will be accessible through Metrodora’s research platform, Metrodora Connect.

Rohit Gupta“We’re excited to begin clinical trials on the new ME/CFS and Long Covid diagnostics at Metrodora,” said Rohit Gupta, Metrodora’s Chief Scientific Officer. “This will give patients early access to their results and will validate our approach to understanding the biological drivers of these diseases and using this to advance care for patients with some of the most debilitating, currently intractable diseases”.

The partners have also identified a number of drug repurposing candidates associated with disease modifying mechanisms in ME/CFS and Long Covid, that if proved well-tolerated and effective in the planned trials, could accelerate the approval of effective new personalized treatments for patients.

Steve Gardner“In Metrodora we have a partner that is moving quickly with us to validate a new generation of precision diagnostics and to generate clinical proof of the disease modifying potential of key disease mechanisms,” said Steve Gardner, PrecisionLife's CEO. “With our combined disease insights, patient support and clinical expertise, we're looking to bring forward new tests for a broad range of underserved patient communities.”

2-Dec-14-2023-09-09-26-7264-PM“Unravelling the mechanistic causes of ME enables us to better diagnose individual patients and identify existing therapies that may be effective in treating them,” added Sonya Chowdhury, CEO of Action for ME. “We hope that actionable clinical trials like these will lead to faster, more accurate diagnosis as well as new treatment options for patients. This will in turn spur on new and much-needed research into the illnesses.”


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About PrecisionLife® 

PrecisionLife is a pioneering precision medicine company changing the way the world predicts, prevents, and treats complex chronic diseases by finding better, more personalized treatment options for patients across the biopharma, diagnostics, and healthcare value chain.

Our combinatorial analytics platform understands disease biology better, identifying disease mechanisms that are relevant to specific patients and the drug targets and treatments that would benefit them.

These unique insights enable us to discover new subgroups of patients with mechanism-based patient stratification biomarkers, identify novel treatment opportunities for unmet medical needs, de-risk and accelerate clinical trials, find new applications for existing drug programs, and build highly predictive complementary diagnostics, personalized risk prediction and disease prevention tools.

To learn more about our groundbreaking work, visit, and follow us on LinkedIn (@PrecisionLife) and X/Twitter (@PrecisionLifeAI).

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About Metrodora Institute

Located in Salt Lake City, Utah, the Metrodora Institute was founded in 2021 with the vision of reimagining care for patients with complex multisystem disorders. Metrodora is uniquely positioned to advance the latest clinical care and develop and commercialize new diagnostic tests and therapeutics for patients living with these often-debilitating conditions. Metrodora Institute has created an innovative offering with a collaborative multidisciplinary approach to medicine. Metrodora currently treats neurological, gastrointestinal, immunological, autoimmune, pain and metabolic disorders. 

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World leading ME/CFS research

For further information about PrecisionLife's groundbreaking research in ME/CFS, click on the link below.


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