Innovation Engine | PrecisionLife

Finding better treatments

Our unique approach powers an Innovation Engine creating new treatment opportunities for precision biopharma and healthcare.

We generate the deepest understanding of the biology driving chronic diseases, stratifying patient populations at an unprecedented resolution to define new subgroups of patients.

With these insights we discover novel drug targets, drug repositioning candidates, and biomarkers to identify the patients who will benefit from them.

Finding better ways to treat disease-min

Creating more personalized therapeutic opportunities from concept to clinic

Chronic diseases, such as dementia, diabetes, cardiovascular and autoimmune disorders, account for over 80% of healthcare spending.

However, they haven’t benefited from advances in genomic medicine as much as cancer or rare diseases because they are caused by a more complex interplay of multiple genes and biological factors.

People with a chronic disease may share a diagnosis, but have different causes of disease and respond to different treatments.

Multiple biological mechanisms can lead to the same clinical symptoms. Depending on which mechanism a drug targets, different treatments will be more successful in some patients than others.

The challenge for biopharma and healthcare is understanding which targets and drugs will work for which subgroups of patients.

We generate patient stratification biomarkers to deliver these precision medicine insights across dozens of chronic diseases.

Discovery

Novel drug targets and indication extension opportunities with patient stratification biomarkers

Development

Biomarkers of drug response to identify patient responders and enrich clinical trials

Diagnosis

Diagnostic biomarkers and combinatorial risk scores

Treatment

Clinical decision support and personalized digital health tools

Combinatorial analytics

Our concept of chronic disease is different from traditional genomic approaches. Instead of looking for variants in single genes to explain disease, we analyze how interactions between multiple, relatively common variants, and other external factors come together to trigger disease processes.

Understanding the non-linear impact of these interactions allows us to perform high-resolution patient stratification, revealing how different aspects of disease biology affect subgroups of patients and enabling us to identify novel drug targets tailored to these patient subgroups.

DiseaseBank™

We’ve now run over 40 chronic disease datasets through our PrecisionLife® combinatorial analytics platform, and we’re analyzing 2 more every month. Our studies have generated deep insights into the mechanisms underpinning every one of these diseases.

We’ve discovered hundreds of new biomarkers that identify clinically relevant patient subgroups who share a disease mechanism, with novel drug targets and indication extension opportunities for treating them. All of these proprietary and protectable insights are stored in our DiseaseBank repository.

OUR PHILOSOPHY

From population to personal

Patient stratification is the key to more personalized precision medicine

We believe that everyone is unique and that the best way to treat disease isn’t always as easy as a “one-size-fits-all” approach defined by a clinical diagnosis or set of broad symptoms.

We analyze disease datasets from consented patient populations to gain a deeper understanding of how biology is driving disease within different patient subgroups.

With these insights, we identifynew and better ways of treating that disease, and to improve the diagnosis and inform the selection of the best medicines for individuals, enabling personalized health at scale.