Type-II diabetes-related complications create some of the most significant health and economic burdens in developed and developing countries. Complications associated with type-II diabetes include renal failure, neuropathies, blindness and cardiovascular impacts including heart disease, stroke, ulcers and amputations. They account for 80% of the huge diabetes treatment costs, and are directly responsible for poor quality of life for patients, with higher long-term social care costs and mortality rates.
We identified 20 genes most closely associated with the risk of developing type-II diabetes complications. We then built combinatorial risk scores that predict which type of complications a type-II diabetes patient is likely to experience.